Senyawa Penciri Ekstrak Daun Jati Belanda (Guazuma ulmifolia Lamk) sebagai Anti-Kolesterol

  • Irmanida Batubara
  • . Husnawati
  • Latifah Kosim Darusman
  • Tohru Mitsunaga
Keywords: anti-cholesterol, Guazuma ulmifolia Lamk, marker compound, quercetin

Abstract

Jati belanda (Guazuma ulmifolia Lamk) leaves is traditionally used as slimming and cholesterol reducing agent. This research aims to determine the active component on jati belanda leaves as marker compound for cholesterol reducing agent. The quality of leaves was checked prior to use for next step of analysis. Jati belanda leaves with good quality was extracted by ethanol 30% and the extract was separated by chromatography technique such as open column chromatography and preparative high performance liquid chromatography. The results showed that the quality of samples is meet to the requirement of Indonesian Food and Drug Agency (Badan Pengawas Obat dan Makanan (BPOM)) based on moisture content, ash content, and heavy metal content. Based on the separation results showed that the cholesterol reducing compound from jati belanda is quercetin

Downloads

Download data is not yet available.

Author Biographies

Irmanida Batubara
Departemen Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor, Kampus IPB Darmaga, Bogor 16680
. Husnawati
Departemen Biokimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor, Kampus IPB Darmaga, Bogor 16680
Latifah Kosim Darusman
Departemen Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam, Institut Pertanian Bogor, Kampus IPB Darmaga, Bogor 16680
Tohru Mitsunaga
Faculty of Applied Biological Science, Gifu University, Japan

References

Acqua SD, Miolo G, Innocenti G, Caffieri S. 2012. The photodegradation of quercetin: relation to oxidation. Molecules. 17(8): 8898-8907. http://doi.org/b9bb

Agustinus. 2009. Studi hematologis potensi metabolik jambu biji merah (Psidium guajava L.) pada penderita demam berdarah dengue. [Skripsi]. Bogor (ID): Institut Pertanian Bogor.

Arima H, Danno G. 2002. Isolation of antimicrobial compounds from guava (Psidium guajava L.) and their structural elucidation. Bioscience Biotechnology Biochemistry. 66(8): 1727-1730. http://doi.org/bpmndq

[BPOM] Badan Pengawas Obat dan Makanan. 2004. Monografi Ekstrak Tumbuhan Obat Indonesia. Jakarta (ID): BPOM RI.

Dinkes Jateng. 2013. Komnas Jamu Beri Sertifikasi Jamu untuk Tekanan dari Tinggi dan Asam Urat. http://www.dinkesjatengprov.go.id/v2012/index.php?option=com_content&view=article&id=103:komnas-jamu-beri-sertikasi-jamu-untuk-tekanan-darah-tinggi-dan-asam-urat&catid=8:latest

Dower JI, Geleijnse JM, Gijsbers L, Zock PL, Kromhout D, Hollman PCH. 2015. Effects of the pure flavonoids epicatechin and quercetin on vascular function and cardiometabolic health: a randomized, double-blind, placebo-controlled, crossover trial. The American Journal of Clinical Nutrition. 101(5): 914-921. http://doi.org/f7bftd

Duenas M, Manzano SO, Paramas AG, Buelga SC. 2009. Antioxidant evaluation of O-methylated metabolites of catechins, epicatechin, and quersetin. Journal of Pharmaceutical and Biomedical Analysis. 51(2): 443-449. http://doi.org/czf3gv

Gitawati R, Widowati L, Suharyanto F. 2015. Penggunaan jamu pada pasien hiperlipidemia berdasarkan data rekam medik, di beberapa fasilitas pelayanan kesehatan di Indonesia. Jurnal kefarmasian Indonesia. 5(1): 41-48. http://doi.org/b9bc

Hayakama M, Itoh M, Ohta K, Li S, Ueda M, Wang MX, Nishida E, Islam S, Suzuki C, Ohazawa K, Kobori M, Inuzuka T. 2015. Quercetin reduces eIF2 phosphorylation by GADD34 induction. Neurobiology of Aging. 36(9): 2509-2518. http://doi.org/b9bd

Manach C, Morand C, Demigné C, Texier O, Régérat F, Rémésy C. 1997. Bioavailability of rutin and quercetin in rats. FEBS Letter. 409(1): 12-16. http://doi.org/dnz8zx

Munawar M, Hartono B, Rifqi S. 2013. LDL Cholesterol Goal Attainment in Hypercholesterolemia: CEPHEUS Indonesian Survey. Acta Cardiologica Sinica. 29(1): 71-81.

Sulistiyani, Kristiani EBE, Darusman LK. 2003. Khasiat hipolipidemia ekstrak heksana dan ekstrak khloroform daun jati belanda (Guazuma ulmifolia Lamk.) Prosiding Seminar Nasional Himpunan Kimia Indonesia (HKI), 21-23 Juli, Malang.

Sun L, Li E, Wang F, Wang T, Qin Z, Niu S, Qiu C. 2015. Quercetin increases macrophage cholesterol efflux to inhibit foam cell formation through activating PPAR-ABCA1 pathway. International Journal of Clinical and Experimental Pathology. 8(9): 10854-10860.

[WHO] World Heath Organization. 2007. Prevention of cardiovascular disease: Pocket Guidelines for Assessment and management of cardiovascular risk. WHO, Geneva (CH).

Yamauchi K, Mitsunaga T, Batubara I. 2014. Synthesis of quercetin glycoside and their melanogenesis stimulatory activity in B16 melanoma cells. Bioorganic & Medicinal Chemistry. 22(3): 937-944. http://doi.org/f5q296

Zhang M, Xie Z, Gao W, Pu L, Wei J, Guo C. 2016. Quercetin regulates hepatic cholesterol metabolism by promoting cholesterol-to-bile acid conversion and cholesterol efflux in rats. Nutrition research. 36(3): 271-279. http://doi.org/f8c8v2

Published
2017-08-21
How to Cite
BatubaraI., Husnawati., DarusmanL. K., & MitsunagaT. (2017). Senyawa Penciri Ekstrak Daun Jati Belanda (Guazuma ulmifolia Lamk) sebagai Anti-Kolesterol. Jurnal Ilmu Pertanian Indonesia, 22(2), 87-91. https://doi.org/10.18343/jipi.22.2.87

Most read articles by the same author(s)

1 2 > >>