Improvement on stability, physical characteristics and physiological activities of vinyl-dithiin has been attempted through oxidation and methylation. A bioautography method with Cladosporium cucumerinum showed that the presence of sulphoxide compound increased the anti-fungal activity sharply. Best activity was obtained with the compounds with SSO functional group. Activity was slightly decreased by addition of methyl-group. Stereoisomer also influenced the activity of compound, although not to significantly. Isomer of 3,4-dihidro-3-isopropenil-5-metil-4H-1, 2-ditiin-1-oxide has interesting properties such as crystallized easily, posses weak odor and relatively strong in anti fungal activity. A Simple methallylsynthesis procedure for disufide has been developed using metallyl chloride as starting material.
WijayaC. H. (2010). Synthesis Of Garlic Compound Vinyl-Dithiin And Its Derivatives, And Their Anti-Fungal Determination Using Bioautography Methode. Jurnal Teknologi Dan Industri Pangan, 11(1), 48. Retrieved from https://jai.ipb.ac.id/index.php/jtip/article/view/914
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