PENGARUH PEMBERIAN BUBUK EKSTRAK CU-TURUNAN KLOROFIL DAUN CINCAU (Premna oblongijolia Merr.) TERHADAP PROFIL LIPID DARAH KELINCI

Nurdin Nurdin, Ali Khomsan, Sri Anna Marliyati, Faisal Anwar, Clara Meliyanti Kusharto, Dewi Ratih Agungpriyono

Abstract


ABSTRACT. The aim of this research was to produce cincau copper-derivative chlorophyll powder and to observe its phYSico-chemical properties and the effect on blood lipid profile of5 month male New Zealand White rabbits. The blood lipid profile observed were total cholesterol, triglyceride, HDL (high-denSity lipoprotein) cholesterol, and LDL (low-density lipoprotein) cholesterol. A two months treatment was conducted A random
block design was applied with the following treatment on each experimental unit: PO (basal diet, negative control), PI (basal diet with cholesterol 0.1% (wlw) added, positive control), P2 (basal diet with cholesterol 0.1% (wlw) and 16.7 mglkg-body weight/d natural chlorophyll powder added), P3 (basal diet with cholesterol 0.1% (wlw) and 16.7 mglkgbody weight/d copper-derivative of chlorophyll powder added), P4 (basal diet with
cholesterol 0.1% (wlw) and 50.1 mglkg-body weightld copper-derivative of chlorophyll powder added}, P5 (basal diet with cholesterol 0.1% (wlw), and 16.7 mglkg-body weight/d
commercial chlorophyll powder added The results of study showed that cincau leaves chlorophyll extract solution with Cu1
+ 100 mglL level produce the cincau copper-derivate chlorophyll powder with highest pH, solubility, and greenness compared to other copper levels. Feeding with copper-derivative of chlorophyll cincau powder (P3) most likely decreased total cholesterol, triglycerides, LDL cholesterol increased the HDL cholesterol,
and decreased atherosclerosis risk after 2 month as compare to feeding contain of natural chlorophyll (P2). Keywords: Premna oblongifolia Merr., copper-derivate chlorophyll powder, total
cholesterol, triglyceride. HDL cholesterol, LDL cholesterol